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Related Experiment Videos

Flushing in rosacea: a possible mechanism.

M Guarrera, A Parodi, C Cipriani

    Archives of Dermatological Research
    |January 1, 1982
    PubMed
    Summary

    This study investigated flushing in rosacea, finding that clonidine effectively reduced symptoms. Bradykinin levels increased during flushing, supporting its role in vasodilation and suggesting epinephrine triggers its release.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Vascular Biology

    Background:

    • Facial flushing is a common and distressing symptom of rosacea.
    • The precise mechanisms underlying rosacea flushing, including the role of specific mediators, require further elucidation.

    Purpose of the Study:

    • To investigate the pharmacological inhibition of potential chemical mediators of flushing in rosacea.
    • To assess the role of bradykinin as a direct effector in rosacea-induced vasodilation.

    Main Methods:

    • Pharmacological agents were used to inhibit suspected chemical mediators of flushing.
    • Bradykinin levels were measured in patients during flushing episodes.
    • The effect of clonidine on flushing severity was evaluated.

    Main Results:

    • Clonidine demonstrated significant inhibition of flushing in all patients, with a mean reduction of 45%.
    • Other pharmacological interventions showed less efficacy.
    • Bradykinin levels increased by a mean of 60% during flushing episodes.

    Conclusions:

    • The findings support the hypothesis that epinephrine-induced bradykinin release is a key factor in rosacea-associated vasodilation.
    • Bradykinin is implicated as a significant mediator in the pathophysiology of rosacea flushing.

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