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Immune interferon (IFN-gamma) production in autologous mixed cultures
T cells were exposed in vitro to autologous B cells or monocytes. Tested on the seventh day, the cultured lymphocytes lysed K562, Daudi, autologous, and allogeneic phytohemagglutinin (PHA) blasts. Autologous B blasts were not affected. The supernatants contained gamma interferon (IFN-gamma). The quantity of IFN did not correlate with the strength of the proliferative response nor with the strength of the cytotoxic potential.
T cells were exposed in vitro to autologous B cells or monocytes. Tested on the seventh day, the cultured lymphocytes lysed K562, Daudi, autologous, and allogeneic phytohemagglutinin (PHA) blasts. Autologous B blasts were not affected. The supernatants contained gamma interferon (IFN-gamma). The quantity of IFN did not correlate with the strength of the proliferative response nor with the strength of the cytotoxic potential.