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Pilot study for large-scale plasma procurement using automated plasmapheresis.

A E Robinson, A F Penny, J Smith

    Vox Sanguinis
    |March 1, 1983
    PubMed
    Summary
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    Large-scale automated plasmapheresis using the Haemonetics Model 50 machine can safely and economically produce sufficient fresh plasma for national factor VIII concentrate production. This pilot study confirms program viability for self-sufficiency in plasma procurement.

    Area of Science:

    • Biomedical Engineering
    • Transfusion Medicine
    • Hematology

    Background:

    • National self-sufficiency in fresh plasma is crucial for factor VIII concentrate production.
    • Existing plasma procurement methods may face limitations in scale and efficiency.
    • Automated plasmapheresis offers potential for increased plasma yields.

    Purpose of the Study:

    • To evaluate the feasibility of large-scale automated plasmapheresis for national plasma procurement.
    • To assess donor safety, recruitment, cost-effectiveness, and anticoagulant choice for optimal factor VIII yields.
    • To determine the viability of achieving national self-sufficiency in fresh plasma.

    Main Methods:

    • A pilot study utilizing the Haemonetics Model 50 automated plasmapheresis machine.

    Related Experiment Videos

  • Conducted in the Yorkshire Region, UK.
  • Focused on donor safety, recruitment strategies, economic analysis, and anticoagulant impact on factor VIII.

    • Main Results:

    • Large-scale automated plasmapheresis demonstrated safety and economic viability.
    • High-quality source plasma was produced, meeting requirements for factor VIII concentrate.
    • The study identified key factors for successful program implementation.

    Conclusions:

    • Automated plasmapheresis is a viable method for large-scale fresh plasma procurement.
    • The program can support national self-sufficiency in plasma for factor VIII production.
    • This approach offers a safe and economical solution for plasma sourcing.