Increased phospholipid methylation in the myocardium of alcoholic rats

Phospholipid methyltransferase activity is unevenly distributed throughout the contractile and the specialized regions of rat heart. Chronic alcohol treatment stimulated the incorporation of [3H-methyl]-methionine but not [3H-methyl]-choline into phosphatidylcholine by left ventricular slices. The increase in the incorporation of [3H-methyl]-group from [3H-methyl]-methionine into phosphatidylcholine was due to an increase in phospholipid methyltransferase activity.