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Cyclic expression of low-dose paralysis.

P W Stashak, C E Taylor, G Caldes

    Cellular Immunology
    |April 1, 1983
    PubMed
    Summary
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    Priming with low-dose pneumococcal polysaccharide induces antigen-specific T-cell paralysis. This unresponsiveness exhibits a cyclic pattern, suggesting cell proliferation is involved in its maintenance.

    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • Prior treatment with subimmunogenic doses of Type III pneumococcal polysaccharide primes the immune system.
    • This priming leads to antigen-specific T-cell-dependent unresponsiveness, termed low-dose paralysis.

    Purpose of the Study:

    • To investigate the temporal dynamics of low-dose paralysis.
    • To explore the role of cell proliferation in maintaining immune unresponsiveness.

    Main Methods:

    • Induction of low-dose paralysis in a model system.
    • Monitoring of immune unresponsiveness and sensitivity over time.
    • Analysis of cellular proliferation patterns.

    Main Results:

    • Low-dose paralysis persists for months but exhibits a cyclic pattern with approximately 3-day periodicity.

    Related Experiment Videos

  • Periods of Velban sensitivity also display a cyclic nature, correlating with unresponsiveness.
  • Evidence suggests ordered cell proliferation is required for maintaining paralysis.

    • Conclusions:

    • Immune unresponsiveness induced by low-dose pneumococcal polysaccharide is not static but dynamically regulated.
    • Cyclic immune responses indicate an ordered, proliferation-dependent mechanism following antigen priming.
    • Further research into these cyclic immune phenomena could inform strategies for immune modulation.