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Pancreatic exocrine function in rosacea.

A Barba, B Rosa, G Angelini

    Dermatologica
    |January 1, 1982
    PubMed
    Summary
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    Rosacea patients may have gastrointestinal issues due to lower lipase secretion from the pancreas. This pancreatic exocrine dysfunction could contribute to rosacea symptoms, suggesting a link between gut health and skin condition.

    Area of Science:

    • Gastroenterology
    • Dermatology
    • Pancreatic Physiology

    Background:

    • Rosacea is a common inflammatory skin condition.
    • Gastrointestinal complaints are frequently reported by rosacea patients.
    • Pancreatic extracts have shown potential in ameliorating both dyspepsia and rosacea skin lesions.

    Purpose of the Study:

    • To investigate the exocrine pancreatic function in patients with rosacea.
    • To compare pancreatic function between rosacea patients and healthy controls.
    • To determine if pancreatic exocrine dysfunction is associated with rosacea.

    Main Methods:

    • Secretin-cerulein infusion test used to assess pancreatic exocrine function.
    • 21 subjects with rosacea and 21 healthy controls were studied.

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  • Analysis included flow rate, bicarbonate, chymotrypsin, and lipase concentrations and outputs.

    • Main Results:

    • No significant differences in flow rate, bicarbonate, or chymotrypsin were observed between groups.
    • Lipase concentration and output were significantly lower in rosacea patients (18.5-66% decrease).
    • This indicates a specific deficiency in lipase secretion in individuals with rosacea.

    Conclusions:

    • Reduced pancreatic lipase secretion may be a contributing factor to rosacea.
    • Pancreatic exocrine dysfunction, particularly lipase deficiency, warrants further investigation in rosacea pathogenesis.
    • Findings suggest a potential link between gastrointestinal function and dermatological manifestations in rosacea.