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Radiation-resistant IgE-secreting cells in the mouse: susceptibility to suppressor T cells
X-irradiation (800 or 1,000 R) of Balb/c mice displaying 'persistent' high-titer anti-ovalbumin IgE responses resulted in only minor decreases in antibody titres measured 40 days later, indicating that the bulk of IgE production could be ascribed to long-lived radiation-resistant (and thus non-dividing) plasma cells. IgE-specific suppressor T cells from ovalbumin-tolerant mice did not affect ongoing persistent IgE synthesis by these plasma cells, but prevented their emergence in ovalbumin-immunized mice and in those adoptively immunized with splenocytes from animals displaying persistent IgE responses.
X-irradiation (800 or 1,000 R) of Balb/c mice displaying 'persistent' high-titer anti-ovalbumin IgE responses resulted in only minor decreases in antibody titres measured 40 days later, indicating that the bulk of IgE production could be ascribed to long-lived radiation-resistant (and thus non-dividing) plasma cells. IgE-specific suppressor T cells from ovalbumin-tolerant mice did not affect ongoing persistent IgE synthesis by these plasma cells, but prevented their emergence in ovalbumin-immunized mice and in those adoptively immunized with splenocytes from animals displaying persistent IgE responses.