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[Pure defibrination after timber rattlesnake bite].

C Bismuth, N Chouvalidze, F Baud

Presse Medicale (Paris, France : 1983)

|January 15, 1983

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Timber rattlesnake bites cause a specific coagulation disorder, leading to a complete absence of fibrinogen. This defibrination persists for 64 hours, even with cryoprecipitate treatment, highlighting the need for lab tests to diagnose venom-induced coagulopathy.

Area of Science:

Toxicology
Hematology
Herpetology

Background:

Snakebite envenomation can cause complex hemostatic abnormalities.
Timber rattlesnakes (Crotalus horridus) are venomous snakes found in North America.
Understanding specific venom effects is crucial for effective treatment.

Observation:

A patient bitten by a timber rattlesnake exhibited a unique coagulation disorder.
The primary observed abnormality was a complete absence of fibrinogen.
This fibrinogen deficiency persisted for 64 hours post-bite.

Findings:

Experimental defibrination was achieved with Crotalus horridus venom.
The coagulation disorder was highly specific to this snake species.
Cryoprecipitate administration did not correct the fibrinogen absence.

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Implications:

The findings underscore the specific coagulopathic effects of Crotalus horridus venom.
Laboratory examination is essential for diagnosing venom-induced coagulopathies.
This specificity challenges generalized treatment protocols for snakebite coagulopathy.