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Lipomodulin: a possible mediator of the action of glucocorticoids
Abstract:
Lipomodulin, a protein with a MW of 40,000, is induced in many cells by glucocorticoids. This protein can mimic a variety of biological activities of glucocorticoids such as anti-inflammation, immunosuppression, and promotion of cellular differentiation. Since anti-lipomodulin antibody can block these effects of both glucocorticoids and lipomodulin, it is quite possible that lipomodulin is a mediator of glucocorticoids.