Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endocrinological studies with desogestrel.

J van der Vies, J de Visser

    Arzneimittel-Forschung
    |January 1, 1983
    PubMed
    Summary

    Desogestrel, a novel progestational steroid, demonstrates high oral activity and potency in contraceptive applications. It surpasses norethisterone and levonorgestrel in progestational and anti-estrogenic effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Architectonic constraints on the hyoid's optimal starting position for suction feeding of fish.

    Journal of morphology·2018
    Same author

    Pharmacokinetics of anabolic steroids.

    Wiener medizinische Wochenschrift (1946)·1993
    Same author

    Pharmacological studies with (7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14).

    Maturitas·1987
    Same author

    Comparison of the receptor binding properties of nandrolone and testosterone under in vitro and in vivo conditions.

    Journal of steroid biochemistry·1985
    Same author

    Enzymatic microdetermination of free fatty acids in plasma of animals using paraoxon to prevent lipolysis.

    Scandinavian journal of clinical and laboratory investigation·1985
    Same author

    Effects of hyperprolactinemia on the accessory sexual organs of the male rat.

    The Prostate·1985

    Area of Science:

    • Endocrinology
    • Pharmacology
    • Reproductive Medicine

    Background:

    • Oral contraceptives require effective progestational steroids.
    • Novel compounds are continuously developed to improve efficacy and safety.
    • Desogestrel (Org 2969) is a new synthetic progestational steroid.

    Purpose of the Study:

    • To evaluate the progestational and anti-estrogenic activities of desogestrel.
    • To compare the potency of desogestrel with established progestins like norethisterone and levonorgestrel.
    • To assess the efficacy of desogestrel in oral contraceptive applications.

    Main Methods:

    • Standardized assays for progestational effects: McPhail test, McGinty test, Deciduoma test.
    • Antifertilization tests were conducted.
    • Ovulation inhibition tests were performed.
    • Oral administration was used for all tests.

    Main Results:

    • Desogestrel exhibited high activity in all tested progestational assays.
    • Desogestrel demonstrated greater potency than norethisterone and levonorgestrel.
    • Significant anti-estrogenic activity was observed for desogestrel.
    • Effective inhibition of ovulation was noted after oral administration.

    Conclusions:

    • Desogestrel is a potent progestational steroid with significant anti-estrogenic properties.
    • Its high oral activity and potency make it a promising candidate for oral contraceptives.
    • Desogestrel represents an advancement over existing progestins like norethisterone and levonorgestrel.

    Related Experiment Videos