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Non-H-2 genes involved in suppressing autoimmunity
Peritoneal cells from C3H mice, after 4 days in culture, comprised a significantly higher number of cells secreting autoantibodies against mouse bromelain-treated red blood cells compared to cells from AKR mice. Females gave higher responses than males. The F1 hybrid of the two strains gave low-level responses similar to AKR mice. Mixtures of cells from males and females and from C3H and AKR mice did not give responses below those expected from the mixed population, which shows that cells from males and from AKR mice did not suppress the high-responder responder populations. However, cells from F1 mice significantly suppressed the response by C3H mice. The suppressor population was adherent to plastic and diminished by anti-Thy 1.2 treatment and complement. These results show that, within genetic constraints that include non-H-2 genes, suppressor cells likely to be T cells from a low-responder strain inhibit the development in vitro of an autoimmune response of a high-responder strain.
Peritoneal cells from C3H mice, after 4 days in culture, comprised a significantly higher number of cells secreting autoantibodies against mouse bromelain-treated red blood cells compared to cells from AKR mice. Females gave higher responses than males. The F1 hybrid of the two strains gave low-level responses similar to AKR mice. Mixtures of cells from males and females and from C3H and AKR mice did not give responses below those expected from the mixed population, which shows that cells from males and from AKR mice did not suppress the high-responder responder populations. However, cells from F1 mice significantly suppressed the response by C3H mice. The suppressor population was adherent to plastic and diminished by anti-Thy 1.2 treatment and complement. These results show that, within genetic constraints that include non-H-2 genes, suppressor cells likely to be T cells from a low-responder strain inhibit the development in vitro of an autoimmune response of a high-responder strain.