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Related Experiment Videos

Reflections on what makes the heart grow.

F Kölbel, V Schreiber, J Stĕpán

    Advances in Myocardiology
    |January 1, 1983
    PubMed
    Summary

    Researchers discovered a digoxin-like substance in rat serum during cardiac overload, suggesting a new cardiotropic factor called endocardin may stimulate heart cell growth.

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    Area of Science:

    • Cardiology
    • Endocrinology
    • Molecular Biology

    Background:

    • Cardiac hypertrophy and overload trigger physiological changes in the heart.
    • Digoxin-like immunoreactivity has been observed in serum under certain conditions.
    • The existence of endogenous cardiotropic factors is under investigation.

    Purpose of the Study:

    • To investigate the origin of digoxin-like immunoreactivity in experimental cardiac overload.
    • To identify a potential endogenous cardiotropic factor involved in cardiac growth.
    • To explore the role of this factor in stimulating cardiac myocyte proliferation.

    Main Methods:

    • Induction of experimental cardiac overload and hypertrophy in rats.
    • Measurement of digoxin-like immunoreactivity in serum.
    • Assessment of serum's effect on rat cardiac myocyte multiplication in tissue culture.
    • Analysis of potential steroid origins.

    Main Results:

    • Digoxin-like immunoreactivity in rat serum correlated with cardiac growth during overload.
    • Sera from overloaded rats stimulated cardiac myocyte proliferation in vitro.
    • The factor demonstrated cross-immunoreactivity with digoxin, suggesting a structural similarity.
    • The factor is hypothesized to be an adrenal steroid distinct from corticosterone and aldosterone.

    Conclusions:

    • An endogenous cardiotropic factor, potentially an adrenal steroid, is present during cardiac overload.
    • This factor exhibits digoxin-like immunoreactivity and stimulates cardiac myocyte growth.
    • The proposed name for this factor is endocardin or endocardiotonin.

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