Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating T cell subsets in euthyroid Graves' disease.

M Bagnasco, G W Canonica, S Ferrini

    Journal of Endocrinological Investigation
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A multicenter real-world, open-label study assessing the impact of a probiotic mixture on symptoms of irritable bowel syndrome in adults.

    Beneficial microbes·2025
    Same author

    Survey on the attitude of Italian allergologists concerning the topical nasal therapy.

    European annals of allergy and clinical immunology·2025
    Same author

    Allergic rhinitis management: a survey on Italian primary care pediatricians.

    European annals of allergy and clinical immunology·2024
    Same author

    A low-dose multicomponent medication as a new approach in prevention and early add-on treatment of recurrent respiratory infections in children: a Delphi Consensus.

    European review for medical and pharmacological sciences·2024
    Same author

    OCULAR DISCOMFORT IN PROFESSIONAL POLO-WATER PLAYERS: A PRACTICAL EXPERIENCE WITH TOPICAL HYALURONIC ACID AND GLYCURONATE ENOXOLONE.

    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2023
    Same author

    Factors associated with asthma exacerbations in schoolchildren: an experience in clinical practice.

    European annals of allergy and clinical immunology·2022

    T cell analysis revealed a decrease in suppressor T cells (TG cells) in euthyroid Graves' disease patients. This finding may support the autoimmune basis of endocrine ophthalmopathy.

    Area of Science:

    • Immunology
    • Endocrinology
    • Autoimmune Diseases

    Background:

    • Graves' disease and Hashimoto's thyroiditis are autoimmune thyroid disorders.
    • T cell subpopulations play critical roles in immune regulation and autoimmunity.
    • Endocrine ophthalmopathy is a common complication of Graves' disease.

    Purpose of the Study:

    • To investigate T cell subpopulations in patients with euthyroid Graves' disease and Hashimoto's thyroiditis with ophthalmopathy.
    • To correlate T cell marker expression with disease status and potential autoimmune pathogenesis.

    Main Methods:

    • Flow cytometry was used to analyze T cell markers.
    • Evaluated Fc receptors for IgG, and antigens MLR4, 5/9, and BT 2/9 (anti-DR).
    • Assessed T cell subpopulations in 12 euthyroid Graves' disease patients and 2 Hashimoto's thyroiditis patients with eye changes.

    Related Experiment Videos

    Main Results:

    • A significant decrease in suppressor T cells (TG cells) was observed in euthyroid Graves' disease patients.
    • Hashimoto's patients with eye changes showed normal or elevated TG cells.
    • Helper T cells (5/9+) and activated T cells (MLR4+, BT 2/9+) were mostly normal in Graves' disease but elevated in Hashimoto's thyroiditis.

    Conclusions:

    • The reduction of TG cells in euthyroid Graves' disease supports their potential role in the disease's autoimmune pathogenesis.
    • Abnormalities in T cell subpopulations may contribute to the development of endocrine ophthalmopathy.
    • Further research into T cell dysregulation is warranted for understanding and treating these thyroid autoimmune conditions.