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Related Experiment Videos

Primitive reflexes in Down's syndrome.

T Sand, S I Mellgren, A Hestnes

    Journal of Mental Deficiency Research
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Primitive reflexes like the palmomental and snout reflexes are more prevalent in individuals with Down's syndrome (DS). The snout reflex may indicate dementia in older DS patients.

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    Area of Science:

    • Neurology
    • Developmental Biology
    • Genetics

    Background:

    • Primitive reflexes are typically present in infants and disappear with neurological development.
    • Alterations in primitive reflexes can indicate neurological dysfunction.
    • Down's syndrome (DS) is associated with developmental delays and potential neurological differences.

    Purpose of the Study:

    • To investigate the prevalence of palmomental, snout, and corneomandibular reflexes in institutionalized patients with Down's syndrome.
    • To compare these reflex prevalences with a control group.
    • To explore potential correlations between reflex presence, age, and degree of intellectual disability in Down's syndrome.

    Main Methods:

    • A study involving 30 institutionalized patients with Down's syndrome and a control group.

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  • Clinical examination to assess the presence and prevalence of three specific primitive reflexes.
  • Statistical analysis to compare reflex rates between groups and examine correlations.

    • Main Results:

    • The palmomental reflex was significantly more prevalent in the Down's syndrome group (47%) compared to controls (7%).
    • The snout reflex was also more common in the Down's syndrome group (14%) than in controls (0%).
    • The snout reflex showed a higher prevalence in Down's syndrome patients over 35 years old (29%) compared to those under 35 (0%), suggesting a potential link to aging or dementia.

    Conclusions:

    • The palmomental and snout reflexes are significantly more prevalent in individuals with Down's syndrome.
    • The corneomandibular reflex was found to be unreliable in this population due to cooperation issues.
    • The snout reflex's increased prevalence in older Down's syndrome patients warrants further investigation as a potential marker for dementia.