Related Experiment Videos
[Clinical use of piperacillin on obstetrical and gynecological infections (Second report)]
Abstract:
We administered piperacillin (PIPC) to patients with obstetrical and gynecological infectious diseases and obtained the following results. 1. Sixteen patients were administered PIPC at a dose of 4 or 9 g by dripping infusion 2 or 3 times a day for a period of 4 approximately 14 days. Eight cases had cancer as their underlying disease (including cervical cancer etc.). The clinical effect was good in 3 of these 8 patients with cancer so that the efficacy rate was 37.5%. But the other 8 cases without cancer all responded effectively, so their efficacy rate was 100%. The efficacy was good in 11 out of 16 cases so the overall efficacy rate was 68.8%. 2. No side effect was observed. 3. No adverse reaction in laboratory findings (including hematological findings, hepatic function tests, renal function tests) was observed.
Insights
Piperacillin (PIPC) effectively treated gynecological and obstetrical infections, showing a 100% efficacy in patients without cancer and a 68.8% overall rate. No adverse effects were noted in this clinical study.
Area of Science:
- Infectious Diseases
- Obstetrics and Gynecology
- Pharmacology
Background:
- Obstetrical and gynecological infections pose significant clinical challenges.
- Effective antibiotic therapy is crucial for managing these conditions.
- Piperacillin (PIPC) is a broad-spectrum antibiotic used to treat bacterial infections.
Observation:
- Sixteen patients with obstetrical and gynecological infections received piperacillin (PIPC).
- Dosing ranged from 4 to 9 g daily, administered via infusion for approximately 14 days.
- Patients included those with underlying conditions such as cancer.
Findings:
- An overall efficacy rate of 68.8% was observed in treated patients.
- Patients without cancer demonstrated a 100% response rate to PIPC.
- Patients with cancer as an underlying disease showed a 37.5% efficacy rate.
- No adverse side effects or laboratory-based adverse reactions were reported.
Implications:
- Piperacillin (PIPC) demonstrates significant clinical efficacy in treating obstetrical and gynecological infections, particularly in patients without comorbidities.
- The antibiotic appears well-tolerated, with a favorable safety profile.
- Further research may explore PIPC's role in specific patient subgroups and optimize treatment protocols.