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[Piperacillin: microbiological and clinical studies].

M L Soranzo, E Capra, G C Angela

    Minerva Medica
    |July 14, 1983
    PubMed
    Summary
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    Piperacillin demonstrates potent in vitro antibacterial activity against various bacteria, including Pseudomonas aeruginosa. Clinical studies show piperacillin is effective in treating infections, making it a versatile therapeutic option.

    Area of Science:

    • Microbiology
    • Clinical Pharmacology

    Background:

    • Piperacillin is an antibiotic with a broad spectrum of activity.
    • Evaluating its efficacy and safety is crucial for clinical application.

    Purpose of the Study:

    • To assess the microbiological and clinical effectiveness of piperacillin.
    • To compare piperacillin's in vitro activity with other antibiotics.

    Main Methods:

    • In vitro susceptibility testing against gram-positive and gram-negative bacteria.
    • Clinical trials involving patients treated with piperacillin.

    Main Results:

    • Piperacillin exhibited excellent in vitro antibacterial action against diverse microorganisms.
    • Significant inhibition of Pseudomonas aeruginosa strains (70.8%) was observed.

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  • In vivo, piperacillin achieved a high rate of clinical and bacteriological cure (35/40 patients).

    • Conclusions:

    • Piperacillin possesses favorable microbiological, pharmacokinetic, and tolerance profiles.
    • Its demonstrated efficacy supports its use for a broad range of therapeutic indications.