Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aspects of chalone action.

W Lehmann, H Graetz, H Schunck

    Acta Histochemica. Supplementband
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Controlled ovarian stimulation (COS) with follitropin delta results in higher cumulative live birth rates compared with follitropin alfa/beta in a large retrospectively analyzed real-world data set.

    Reproductive biology and endocrinology : RB&E·2025
    Same author

    Final Results of GERDA on the Two-Neutrino Double-β Decay Half-Life of ^{76}Ge.

    Physical review letters·2023
    Same author

    Search for tri-nucleon decays of <math></math>Ge in GERDA.

    The European physical journal. C, Particles and fields·2023
    Same author

    Liquid argon light collection and veto modeling in GERDA Phase II.

    The European physical journal. C, Particles and fields·2023
    Same author

    Development of a digital twin of a tablet that mimics a real solid dosage form: Differences in the dissolution profile in conventional mini-USP II and a biorelevant colon model.

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2022
    Same author

    Erratum: First Search for Bosonic Superweakly Interacting Massive Particles with Masses up to 1  MeV/c^{2} with GERDA [Phys. Rev. Lett. 125, 011801 (2020)].

    Physical review letters·2022

    Chalone-like factors inhibit cell proliferation, particularly in rapidly growing cancer cells. These inhibitors are counteracted by specific growth factors, influencing cell cycle progression.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Oncology

    Background:

    • Chalones are endogenous inhibitors of cell proliferation.
    • Understanding chalone action is crucial for developing cancer therapies.
    • Ehrlich ascites mammary carcinoma and granulocytic cells serve as models for studying chalone mechanisms.

    Purpose of the Study:

    • To investigate the action of a chalone-like factor on Ehrlich ascites mammary carcinoma.
    • To examine the properties of granulocytic chalone.
    • To elucidate the dependence of chalone action on cell proliferation state and its antagonism with growth factors.

    Main Methods:

    • Analysis of chalone-like factor action on cancer cells.
    • Investigation of antagonism with insulin, proinsulin, and colony-stimulating factor.

    Related Experiment Videos

  • Flow cytometry used to study effects on cell cycle progression.

    • Main Results:

    • Chalone-like factors show poor or no response in rapidly proliferating cells.
    • Ehrlich ascites mammary carcinoma factor is antagonized by insulin/proinsulin.
    • Granulocytic chalone is antagonized by colony-stimulating factor.

    Conclusions:

    • Chalone activity is inversely related to cell proliferation rate.
    • Specific growth factors antagonize chalone effects, suggesting a regulatory interplay.
    • Further research is needed to fully analyze chalone influence on cell cycle progression.