Complications of Paget's disease of bone

This paper describes the diverse complications of Paget's osteopathy. Lesions arising from changes in the bone per se, those due to secondary anatomical changes, and metabolic abnormalities, are discussed in relation to their presentation, frequency, and severity. Important complications involving the skeletal structures and nervous system are described. Sarcomatous change in the abnormal bone remains the most serious lesion. Some changes recognised for decades, such as high output heart failure, are very rare. Other less-well-recognised features, including hyperuricaemia, may be common enough to justify simple screening tests for their detection whenever Paget's disease presents clinically.