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Related Experiment Videos

Accessory cell-dependent selection of specific T-cell functions.

G Ramila, P Erb

    Nature
    |August 4, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Antigen-presenting accessory cells, like macrophages, are crucial for T-cell activation. Some tumor cells can activate T-cell proliferation but may also induce suppressor T cells, hindering immune responses.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • T-cell activation relies on interactions with antigen-presenting accessory cells expressing I region associated (Ia) products.
    • Accessory cells include macrophages, dendritic cells, B cells, and certain tumor cell lines.
    • Previous studies showed normal macrophages induce T-cell proliferation and help, while some Ia+ tumor lines only stimulate proliferation.

    Purpose of the Study:

    • To investigate how accessory cells influence T-cell function during initial activation.
    • To determine if tumor cell lines can induce suppressor T cells.

    Main Methods:

    • In vitro T-cell activation assays using normal peritoneal exudate macrophages (PEC) and Ia+ tumor cell lines.
    • Analysis of T-cell proliferation and T-cell help induction.
    • Assessment of suppressor T-cell activity.

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    Main Results:

    • Accessory cells (PEC and tumor cells) select specific T cells to express defined functions during initial activation.
    • Certain tumor cell lines, while promoting T-cell proliferation, failed to induce significant T-cell help.
    • Some tumor cell lines were found to induce suppressor T cells that inhibit helper T-cell activity.

    Conclusions:

    • Accessory cells play a selective role in dictating T-cell functional outcomes post-activation.
    • Tumor-associated accessory cells can have distinct immunomodulatory effects, including the induction of immunosuppression via suppressor T cells.