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Related Experiment Videos

Clinical utilization of injectable collagen.

E N Kaplan, E Falces, H Tolleth

    Annals of Plastic Surgery
    |June 1, 1983
    PubMed
    Summary

    Injectable calfhide collagen (Zyderm Collagen Implant) effectively treats soft-tissue defects with advantages in simplicity and safety. Long-term persistence of correction is variable but generally extends beyond twelve months for most patients.

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    Area of Science:

    • Dermatology
    • Plastic Surgery
    • Biomaterials

    Background:

    • Injectable calfhide collagen (Zyderm Collagen Implant) was introduced in 1977 for soft-tissue augmentation.
    • Extensive clinical trials involving over 5,000 patients led to FDA marketing clearance.
    • Physicians have utilized this collagen implant for various cosmetic and reconstructive applications.

    Purpose of the Study:

    • To assess the efficacy and safety of injectable collagen implants based on six years of clinical experience.
    • To evaluate the long-term persistence of correction for soft-tissue depressions treated with collagen.
    • To provide a state-of-the-art assessment of injectable collagen as a therapeutic tool.

    Main Methods:

    • Analysis of clinical data from over 400 patients treated with injectable collagen for facial cutaneous defects.
    • Review of outcomes from a nationwide clinical trial involving 728 physicians.
    • Longitudinal observation of treatment persistence over a minimum of twelve months post-therapy.

    Main Results:

    • Injectable collagen demonstrated effectiveness in correcting various soft-tissue depressions, including those from surgery, acne, and aging.
    • Simplicity of administration and safety were identified as significant advantages.
    • The majority of patients maintained improvements for twelve months or longer, though persistence varied.

    Conclusions:

    • Injectable collagen is an effective tool for specific soft-tissue defects, offering a valuable adjunct to surgical procedures.
    • The primary benefits include ease of use and a favorable safety profile.
    • While effective, the long-term persistence of injectable collagen requires further confirmation.

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