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Moxalactam penetration of normal and osteomyelitic bone
Archives of Orthopaedic and Traumatic Surgery. Archiv Fur Orthopadische Und Unfall-Chirurgie
|January 1, 1983
Abstract:
The ability of moxalactam, a new cephalosporin, to cross the capillary membrane and enter the interstitial fluid space of normal and osteomyelitic bone in the dog was investigated. Moxalactam was noted to readily traverse the capillary membrane of both normal and osteomyelitic bone. The calculated concentrations of moxalactam in the interstitial fluid space corresponded to the simultaneously obtained serum concentrations determined with a bioassay.
Insights
Moxalactam, a new cephalosporin antibiotic, effectively penetrates bone tissue in dogs. This study confirms its ability to reach therapeutic levels in both healthy and infected bone.
Area of Science:
- Pharmacology
- Bone Biology
- Infectious Diseases
Background:
- Osteomyelitis is a challenging bone infection.
- Effective antibiotic penetration into bone is crucial for treatment.
- Moxalactam is a novel cephalosporin with potential antibacterial activity.
Purpose of the Study:
- To investigate moxalactam's ability to cross capillary membranes into bone.
- To determine moxalactam distribution in normal and osteomyelitic bone in dogs.
Main Methods:
- Investigated moxalactam's capillary membrane permeability in canine bone.
- Measured moxalactam concentrations in interstitial fluid and serum via bioassay.
Main Results:
- Moxalactam readily crossed capillary membranes in both normal and osteomyelitic bone.
- Interstitial fluid concentrations of moxalactam correlated with serum concentrations.
Conclusions:
- Moxalactam demonstrates excellent penetration into canine bone tissue.
- The drug achieves therapeutic concentrations in both healthy and infected bone, suggesting potential for osteomyelitis treatment.