[Early pulmonary lesions from hyperoxia in rats]

Normal rats exposed during one hour to pure normobaric oxygen, present pulmonary parenchymatous lesions: diffuse congestion, subpleural atelectasis in dissiminated small areas and hemorragic infarcts. Neither alveolar oedema nor abnormal vascular permeability have been observed. The lesions are not suppressed by pretreatment with promethazine (1 or 2 mg. 100 g-1).