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Related Experiment Videos

Lower limb angiography in leprosy.

A C Johnson, R Reddy, S Johnson

    Radiology
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Angiography revealed narrowed leg arteries and reduced blood flow in leprosy patients, often preceding visible symptoms. These vascular changes, including abnormal fistulas, are linked to inflammation and trophic ulcers, aiding in leprosy management.

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    Area of Science:

    • Vascular Medicine
    • Infectious Diseases
    • Radiology

    Background:

    • Leprosy can cause significant vascular complications.
    • Early detection of vascular changes is crucial for managing leprosy and its sequelae.
    • Angiography is a key diagnostic tool for evaluating peripheral vascular disease.

    Purpose of the Study:

    • To investigate and characterize the angiographic findings in the lower limbs of patients with leprosy.
    • To compare vascular abnormalities in leprosy patients versus a control group without leprosy.
    • To determine if angiographic findings precede clinical manifestations of leprosy.

    Main Methods:

    • Bilateral lower limb angiography was performed on 58 leprosy patients and 63 non-leprosy controls.
    • Vessel caliber, blood flow, and presence of arteriovenous fistulas were assessed.

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  • Histopathological correlation with deep inflammatory granulomatous reactions was considered.

    • Main Results:

    • Leprosy patients exhibited significantly narrower and constricted lower limb vessels compared to controls.
    • Reduced arterial blood flow was observed in the distal third of the lower limbs in leprosy patients.
    • Abnormal arteriovenous fistulas were identified in the thigh, calf, and feet of leprosy patients, associated with trophic ulcers.

    Conclusions:

    • Angiographic findings in leprosy include arterial narrowing, decreased distal blood flow, and arteriovenous fistulas, likely due to deep inflammatory reactions.
    • These vascular changes are specific to leprosy, can precede clinical symptoms, and are valuable for disease management.
    • The observed vascular abnormalities correlate with the development of trophic ulcers in leprosy patients.