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Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1
Abstract:
An assessment of the importance of mink cell focus-inducing (MCF)-type recombinant murine leukemia viruses in spontaneous thymic lymphomagenesis and of the genetic factors affecting its occurrence was carried out with F1 hybrids between AKR and various other inbred strains. There was generally close agreement between the frequency of detection of MCF virus, of thymocyte antigenic amplification in the preleukemic period, and of spontaneous lymphoma. Also, hybrid combinations with moderate to high spontaneous lymphoma were uniformly susceptible to lymphoma induction by neonatal inoculation of MCF 247 virus, while lower leukemic hybrids were at least partially resistant to the induced disease. At least four resistance genes can be identified as affecting the disease in the various hybrids: Fv-1, Rmcf, an unidentified gene carried by the C57 series of mice and SJL, and an unidentified minor gene carried by several other strains.
Insights
Mink cell focus-inducing (MCF)-type viruses are important in spontaneous thymic lymphoma development. Genetic factors, including Fv-1 and Rmcf, influence lymphoma susceptibility in mice.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- Spontaneous thymic lymphomagenesis in mice is a complex process.
- Mink cell focus-inducing (MCF)-type recombinant murine leukemia viruses are implicated in lymphoma development.
Purpose of the Study:
- To assess the role of MCF-type viruses in spontaneous thymic lymphomagenesis.
- To identify genetic factors influencing lymphoma occurrence in F1 hybrid mice.
Main Methods:
- Cross-breeding AKR mice with other inbred strains to create F1 hybrids.
- Monitoring MCF virus detection, thymocyte antigenic amplification, and lymphoma incidence.
- Assessing lymphoma induction by MCF 247 virus in different hybrid combinations.
Main Results:
- Close correlation observed between MCF virus detection, thymocyte changes, and spontaneous lymphoma frequency.
- Hybrid mice with moderate to high spontaneous lymphoma rates were susceptible to MCF virus-induced lymphoma.
- Lower leukemic hybrid groups showed partial resistance to induced lymphoma.
Conclusions:
- MCF-type viruses play a significant role in spontaneous thymic lymphomagenesis.
- At least four distinct genetic loci (Fv-1, Rmcf, and two unidentified genes) confer resistance to lymphoma development in mice.
