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Related Experiment Videos

[D-xylose absorption test. A pharmacokinetic and statistical study].

P Huguenin, B Cochet, L Balant

    Schweizerische Medizinische Wochenschrift
    |February 11, 1978
    PubMed
    Summary

    D-xylose pharmacokinetics shows significant variability in absorption and blood levels among healthy individuals. Urinary excretion alone is not a reliable indicator of intestinal D-xylose absorption.

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    Area of Science:

    • Pharmacokinetics
    • Human Physiology
    • Gastrointestinal Absorption

    Context:

    • The D-xylose absorption test is commonly used to assess intestinal function.
    • Variability in D-xylose pharmacokinetics can impact test interpretation.
    • Understanding D-xylose behavior in different physiological states is crucial.

    Purpose:

    • To investigate the pharmacokinetics of D-xylose in healthy subjects and patients with specific conditions.
    • To evaluate the influence of oral and intravenous D-xylose administration on blood and urinary levels.
    • To determine the reliability of D-xylose urinary excretion as a sole indicator of intestinal absorption.

    Summary:

    • D-xylose pharmacokinetics were assessed in 6 healthy subjects and patients with obesity, renal/hepatic insufficiency, or T-drain post-cholecystectomy.
    • Significant interindividual variations in D-xylose absorption rate, completeness, and distribution volume were observed.
    • Renal insufficiency prolonged D-xylose elimination half-life and reduced renal excretion, highlighting test limitations.

    Impact:

    • Provides pharmacokinetic evidence for the wide range of blood and urinary levels in D-xylose tolerance tests.
    • Demonstrates that D-xylose urinary excretion is not a standalone reliable index of intestinal absorption.
    • Informs clinical interpretation of the D-xylose test, especially in patients with impaired renal function.

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