[Frequencies of ABO system blood groups and haptoglobins in Uzbekistan. The problems of sampling studies]

The results of the analysis of the distribution of blood group gene frequencies of ABO and haptoglobins (Hp) systems for four regions of Uzbek SSR are presented. Three sources were used for sampling: 1) subtotal population samples in 6 villages (the total of 1839 specimens were assayed for ABO and 1729 for Hp); 2) unselected sampling among school children from some districts (2662 specimens assayed for ABO and 3582 for Hp systems); 3) sampling in 18 955 random philanthropic donors from various districts of Uzbekistan. Estimations of blood group gene frequencies were obtained: for the first source--IO = 0.5291; IA = 0.2529; IB = 0.2180; HpI = 0.2510. For the second source--IO = 0.5549; IA = 0.2434; IB = 0.2017; HpI = 0.2783. For the third source--IO = 0.5614; IA = 0.2404; IB = 0.1982. It was established that the frequencies of O(1) blood group of ABO system were permanently increasing, from the values obtained in subtotally investigated villages (kishlaks) toward sampling among school children and reaching the highest value obtained from the sampling in random philanthropic donors (0.5291 leads to 0.5549 leads to 0.5614). The differences are statistically significant. There is strong evidence that it is important for the sampling to be corresponding to the sex-age distribution of populations studied.