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Related Experiment Videos

Normal helper T-cell function in hairy-cell leukaemia.

R Foa, F Lauria, D Raspadori

    Scandinavian Journal of Haematology
    |October 1, 1983
    PubMed
    Summary
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    Peripheral blood T-lymphocyte function remains normal in hairy-cell leukaemia (HCL) patients, including their ability to support B-lymphocyte differentiation. This preserved T-cell function correlates with normal humoral immunity in HCL.

    Area of Science:

    • Immunology
    • Hematology
    • Oncology

    Background:

    • Hairy-cell leukaemia (HCL) is a rare B-cell malignancy.
    • T-cell dysfunction has been observed in other B-cell leukaemias, such as B-cell chronic lymphocytic leukaemia (B-CLL).
    • The functional status of T-lymphocytes in HCL is not well-characterized.

    Purpose of the Study:

    • To evaluate the function of peripheral blood T-lymphocytes in untreated patients with HCL.
    • To investigate T-lymphocyte colony-forming capacity and helper function in HCL.
    • To correlate T-cell function with T-lymphocyte subset distribution and humoral immunity in HCL.

    Main Methods:

    • Assessed in vitro T-colony forming capacity in 22 HCL patients.
    • Evaluated T-cell helper function in a pokeweed mitogen (PWM) stimulated B-lymphocyte differentiation system.

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  • Analyzed T-lymphocyte subsets (OKT4+, OKT8+) using monoclonal antibodies.

    • Main Results:

    • T-colony forming capacity was normal in 20 of 22 HCL patients.
    • T-cell helper function was similar to normal T-cells in all 6 cases studied.
    • T-cell function was independent of T-lymphocyte subset distribution, despite observed increases in OKT8+ and decreases in OKT4+ cells in some patients.

    Conclusions:

    • Peripheral blood T-lymphocyte function is preserved in HCL.
    • The normal T-cell function in HCL aligns with the generally normal humoral immunity observed in this disease.
    • Unlike other B-cell leukaemias, HCL does not appear to be characterized by significant T-cell functional abnormalities.