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Bronchial carcinoids and hormonal disorder.

C Marks, P H Marks

    Southern Medical Journal
    |February 1, 1978
    PubMed
    Summary

    Bronchial carcinoid tumors are linked to hormonal disorders, with two of 24 patients showing polyendocrine issues. This association stems from the shared neural crest origin of carcinoid and endocrine cells.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Neuroscience

    Background:

    • Bronchial carcinoid tumors are neuroendocrine neoplasms.
    • Hormonal disorders can arise from various endocrine gland dysfunctions.
    • The APUD (amine precursor uptake and decarboxylation) cell system links neuroendocrine tumors and endocrine glands.

    Observation:

    • A study reviewed 24 patients with bronchial carcinoid tumors.
    • Two patients in the series exhibited symptoms of polyendocrine disorder.
    • This suggests a potential connection between bronchial carcinoids and hormonal imbalances.

    Findings:

    • The common embryological origin of bronchial carcinoids and endocrine tumors from neural crest ectoderm is a key factor.
    • This shared origin explains the observed association between bronchial carcinoid tumors and endocrine adenomas or carcinomas.
    • The findings highlight a potential link between respiratory and endocrine system pathologies.

    Implications:

    • Understanding this link can improve diagnosis and management of patients with bronchial carcinoids.
    • Further research into the shared developmental pathways may reveal new therapeutic targets.
    • This association underscores the importance of a multidisciplinary approach in managing complex cases.

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