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Myocardial hypertrophy and cardiac failure: a complex interrelationship.

B M Massie

    The American Journal of Medicine
    |September 26, 1983
    PubMed
    Summary

    Myocardial hypertrophy, or heart muscle thickening, has a complex relationship with heart function. While sometimes a sign of impending heart failure in hypertension, it can also be a compensatory response to heart conditions.

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    Area of Science:

    • Cardiology
    • Physiology

    Background:

    • The relationship between myocardial hypertrophy and cardiac function is intricate.
    • Left ventricular hypertrophy in hypertension can precede heart failure.
    • Hypertrophy can act as a compensatory mechanism in various heart diseases.

    Purpose of the Study:

    • To review experimental and clinical data on the development of myocardial hypertrophy.
    • To examine the link between myocardial hypertrophy and myocardial function.

    Main Methods:

    • Review of experimental data.
    • Review of clinical data.

    Main Results:

    • Myocardial hypertrophy's role varies depending on the underlying condition.
    • In hypertension, hypertrophy may signal poor prognosis.
    • In other diseases, hypertrophy is a compensatory response.

    Conclusions:

    • The evolution of hypertrophy and its impact on function are condition-dependent.
    • Understanding this interrelationship is crucial for managing heart disease.

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