Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biochemical regulators in cardiac hypertrophy.

F Kölbel, V Schreiber

    Basic Research in Cardiology
    |July 1, 1983
    PubMed
    Summary

    Researchers identified a potential steroid factor, "endocardin," produced by the adrenal gland. This factor may activate myocardial protein synthesis and increase during cardiac hypertrophy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Definitions matter: detection rates and perinatal outcome for infants classified prenatally as having late fetal growth restriction using SMFM biometric vs ISUOG/Delphi consensus criteria.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
    Same author

    Expanding functions of ADP-ribosylation in the maintenance of genome integrity.

    Seminars in cell & developmental biology·2016
    Same author

    Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.

    Gut·2016
    Same author

    [The role of PARP2 in DNA repair].

    Molekuliarnaia biologiia·2015
    Same author

    PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

    Cell death and differentiation·2014
    Same author

    Recurrent intrahepatic dislocation of ventriculoperitoneal shunt.

    Minimally invasive neurosurgery : MIN·2011

    Area of Science:

    • Cardiovascular physiology
    • Endocrinology
    • Biochemistry

    Background:

    • Muscle tissue responds to mechanical stimuli by altering biochemical processes.
    • The myocardium may produce factors activating protein synthesis.
    • Cardiac hypertrophy involves adaptive changes in the adrenal gland (medulla and cortex).

    Purpose of the Study:

    • To investigate the existence and nature of an endogenous cardiotonic agent.
    • To explore the role of adrenal gland-produced factors in cardiac function.
    • To propose a novel term for this potential endogenous agent.

    Main Methods:

    • Analysis of biochemical responses in muscle to mechanical stimuli.
    • Investigation of adaptive alterations in the adrenal gland during experimental cardiac hypertrophy.
    • Detection of cross-reactivity between digitalis glycosides and steroid hormones.

    Main Results:

    • Cross-reactivity observed between digitalis glycosides and steroid hormones suggests a shared structural or functional characteristic.
    • Evidence points to the adrenal gland as a source of a steroid-like factor.
    • This factor is hypothesized to be an endogenous cardiotonic agent, potentially increasing during cardiac hypertrophy.

    Conclusions:

    • A steroid-like endogenous factor, potentially produced by the adrenal gland, may play a role in cardiac function.
    • This factor, proposed as 'endocardin' or 'endocardiotonin,' might be involved in activating myocardial protein synthesis.
    • Further research is warranted to confirm the existence and function of endocardin in cardiac physiology and hypertrophy.

    Related Experiment Videos