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Long acting injectable hormonal contraceptives.

I S Fraser

    Clinical Reproduction and Fertility
    |March 1, 1982
    PubMed
    Summary
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    Injectable hormonal contraceptives, like depot medroxyprogesterone acetate (DMPA), offer effective birth control with a strong safety profile. Despite some disadvantages, ongoing research aims to improve acceptability and address concerns.

    Area of Science:

    • Reproductive Health
    • Endocrinology
    • Contraception

    Background:

    • Injectable hormonal contraceptives are widely used for birth control.
    • Key preparations include depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-OEN).
    • Other injectable methods are under clinical investigation.

    Purpose of the Study:

    • To review the efficacy, safety, and public perception of injectable hormonal contraceptives.
    • To compare injectable contraceptives with other birth control methods.
    • To discuss the future of injectable contraception in family planning.

    Main Methods:

    • Review of extensive clinical trial data for DMPA (Depo-Provera).
    • Analysis of safety profiles compared to combined oral contraceptives, IUDs, and sterilization.
    Keywords:
    BiologyCancerContraceptionContraception Continuation--statisticsContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, Progestin--pharmacodynamicsContraceptive Agents--pharmacodynamicsContraceptive EffectivenessContraceptive Methods--side effectsContraceptive UsageDiseasesFamily PlanningInjectables--side effectsLactationLiterature ReviewMaternal PhysiologyMedroxyprogesterone Acetate--pharmacodynamicsMenstruationMenstruation DisordersMetabolic EffectsNeoplasmsNorethindrone Enanthate--pharmacodynamicsNorethindrone--pharmacodynamicsPhysiologyReproductionReproductive Control AgentsReversibilitySteroid Metabolic EffectsUse-effectiveness

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  • Examination of reported disadvantages, including menstrual irregularities and delayed fertility return.

    • Main Results:

    • Depot medroxyprogesterone acetate (DMPA) demonstrates a remarkable safety record, comparable to other established contraceptive methods.
    • Despite safety data, DMPA has faced unjustified criticism from certain groups.
    • Menstrual disturbances and delayed fertility return are noted disadvantages.

    Conclusions:

    • Injectable contraceptives, particularly DMPA, are safe and effective options for family planning.
    • Future developments are expected to enhance current formulations and address existing concerns.
    • Increased informed debate is needed to promote wider acceptance of injectable contraceptives.