[Effectiveness of selection taking into account differences in parental couples for histocompatibility antigens]

The connection of the histoincompatibility antigens, determined by the reaction in a mixed culture of lymphocytes of the pair of parents, with the litter of linear mice and live weight of cattle was studied. It was ascertained that the degree of the difference between mates for histocompatibility locus correlated with fruitfulness and productive qualities of the descendants. As a result, a greater quantity of descendants of animals, being more viable, are born. The descendants of the parents, having the high indexes of the reaction in the mixed culture of lymphocytes, are born larger and stronger and retain this advantage during succeeding life periods. The reaction in monozygotic twins has a minimum index. The index of the reaction increases when the relationship between individuals decreases. The method of mixed culture of lymphocytes can be used for prognosis of pairs' combination, for maintenance of the heterogeneity and for determination of the degree of relationship between animals.