Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human C3b receptor.

D T Fearon

    Springer Seminars in Immunopathology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    The C3b receptor, a glycoprotein on various human cells, exhibits structural and numerical variations. Its deficiency is linked to immune complex diseases like SLE and glomerulonephritis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Cellular receptors for fragments of the third component of complement.

    Immunology today·2014
    Same author

    Arrested differentiation, the self-renewing memory lymphocyte, and vaccination.

    Science (New York, N.Y.)·2001
    Same author

    IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19.

    European journal of immunology·2001
    Same author

    Innate immunity--beginning to fulfill its promise?

    Nature immunology·2001
    Same author

    Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

    The Journal of experimental medicine·2000
    Same journal

    Antibody and complement-dependent viral neutralization.

    Springer seminars in immunopathology·2020
    Same journal

    Antibody mediated complement dependent lysis of virus infected cells.

    Springer seminars in immunopathology·2020
    Same journal

    Activating and inhibitory FcgammaRs in autoimmune disorders.

    Springer seminars in immunopathology·2006
    Same journal

    Injecting drugs of abuse and immunity: implications for HIV vaccine testing and efficacy.

    Springer seminars in immunopathology·2006
    Same journal

    Fcepsilon- and Fcgamma-receptor signaling in diseases.

    Springer seminars in immunopathology·2006
    Same journal

    Fc gamma receptors and cancer.

    Springer seminars in immunopathology·2006
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology
    • Genetics

    Background:

    • The C3b receptor (CR1) is a single-chain glycoprotein found on erythrocytes, neutrophils, monocytes, B cells, T cells, and glomerular podocytes.
    • CR1 exists in two allotypic forms (F and S) with different molecular weights.
    • Erythrocyte CR1 numbers vary significantly among individuals and are genetically controlled.

    Purpose of the Study:

    • To investigate the structural and functional characteristics of the C3b receptor.
    • To explore the regulation of C3b receptor expression.
    • To understand the role of C3b receptors in immune complex clearance and disease pathogenesis.

    Main Methods:

    • Biochemical characterization of CR1 allotypes.
    • Genetic analysis of CR1 polymorphism.

    Related Experiment Videos

  • In vitro studies on neutrophil CR1 expression regulation.
  • Cellular assays for CR1-mediated functions (phagocytosis, endocytosis).
  • Analysis of CR1 deficiency in patients with SLE and glomerulonephritis.

    • Main Results:

    • CR1 expression on neutrophils can be rapidly increased by C5adesArg, a phenomenon observed in hemodialysis patients.
    • CR1 associates with the cytoskeleton in monocytes and neutrophils, mediating phagocytosis and endocytosis.
    • CR1 possesses cofactor activity, promoting C3b cleavage, which aids immune complex clearance.
    • Partial deficiency of erythrocyte CR1 in SLE patients and absence of glomerular CR1 in glomerulonephritis patients are linked to impaired immune complex clearance.

    Conclusions:

    • The C3b receptor plays a crucial role in immune complex homeostasis.
    • Genetic and environmental factors influence CR1 expression and function.
    • CR1 deficiency contributes to the pathogenesis of systemic and organ-specific immune complex diseases.