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Related Experiment Videos

Is "subcortical dementia" a recognizable clinical entity?

R Mayeux, Y Stern, J Rosen

    Annals of Neurology
    |September 1, 1983
    PubMed
    Summary
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    The concept of subcortical dementia is misleading. Neuropsychological impairment patterns are not distinct across Alzheimer's, Parkinson's, and Huntington's diseases, with depression impacting cognitive decline.

    Area of Science:

    • Neurology
    • Neuropsychology

    Background:

    • The concept of "subcortical dementia" lacks clear clinical and pathological validation.
    • Dementia is often associated with Alzheimer's disease, but Parkinson's and Huntington's disease also present with cognitive decline.

    Purpose of the Study:

    • To investigate the neuropsychological profiles of patients with Alzheimer's, Parkinson's, and Huntington's disease.
    • To assess the validity of the "subcortical dementia" concept.

    Main Methods:

    • A quantitative neuropsychological assessment was administered to over 100 patients with Alzheimer's, Parkinson's, or Huntington's disease.
    • Patients were categorized into three functional disability stages.

    Main Results:

    • Alzheimer's disease patients showed greater intellectual impairment than Parkinson's or Huntington's disease patients across all stages.

    Related Experiment Videos

  • Dementia criteria were met by all Alzheimer's patients, but only half of those with Parkinson's or Huntington's disease.
  • Depression was present in half of Parkinson's and Huntington's disease patients and correlated with intellectual decline, unlike in Alzheimer's disease.

    • Conclusions:

    • The concept of "subcortical dementia" is misleading due to indistinct neuropsychological impairment patterns.
    • Dementia in these diseases may stem from combined cortical and subcortical degeneration.