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Retinoid therapy is associated with excess granulation tissue responses
Journal of the American Academy of Dermatology
|November 1, 1983
Summary
Excessive granulation tissue growth occurred in eight patients undergoing retinoid therapy for acne and psoriasis. This side effect, linked to isotretinoin and etretinate, sometimes necessitated treatment cessation but wasn't dose-dependent.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Isotretinoin and etretinate are retinoids used to treat severe acne and psoriasis, respectively.
- Retinoids are known for their diverse effects on skin cell proliferation and differentiation.
Observation:
- During clinical trials, eight patients exhibited excessive granulation tissue formation.
- This adverse effect was observed in patients receiving isotretinoin for cystic acne and etretinate for psoriasis.
Findings:
- Granulation tissue appeared in resolving acne lesions in one isotretinoin patient.
- In etretinate-treated psoriasis patients, granulation tissue typically formed near the nail plates.
- Two patients discontinued retinoid therapy due to this side effect.
Implications:
- Excessive granulation tissue is a potential, though uncommon, adverse effect of isotretinoin and etretinate.
- The occurrence of this side effect may warrant closer monitoring in patients undergoing retinoid therapy.
- Further investigation may be needed to understand the mechanism and management of retinoid-induced granulation tissue.