Cation permeability induced by two 15-O5 macrocyclic polyether carriers in phospholipidic large unilamellar vesicles

Sodium permeability in phospholipidic large unilamellar vesicles induced by two 15-O5 macrocyclic polyether derivatives, a carboxylic one 1a and a neutral one 1b, has been studied. The neutral derivative, 1b, appears to behave as a classical mobile carrier such as valinomycin and the carboxylic carrier, 1a, as an ionophore of the nigericin group.