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Related Concept Videos

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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Internal Receptors01:31

Internal Receptors

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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
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Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

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Overview
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Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Related Experiment Video

Updated: Feb 9, 2026

The Multifaceted Benefits of Protein Co-expression in Escherichia coli
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The Multifaceted Benefits of Protein Co-expression in Escherichia coli

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Phage lambda receptor (lamB protein) in Escherichia coli.

M Schwartz

    Methods in Enzymology
    |January 1, 1983
    PubMed
    Summary

    The lambda receptor is a well-studied membrane protein, ideal for investigating structure-function relationships. Its properties also make it a good model for studying protein export to extracytoplasmic locations.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Structural Biology

    Background:

    • The lambda receptor is a key membrane protein.
    • Understanding membrane protein structure-function is crucial in molecular biology.

    Purpose of the Study:

    • To summarize the properties of the lambda receptor.
    • To highlight its utility in studying membrane protein structure-function.
    • To present it as a model for protein export.

    Main Methods:

    • Genetic techniques
    • Biophysical techniques
    • Biochemical techniques

    Main Results:

    • The lambda receptor exhibits properties amenable to diverse study methods.

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  • It serves as an excellent model for investigating membrane protein structure-function.
  • It is also suitable for studying protein export mechanisms.

    • Conclusions:

    • The lambda receptor is a valuable model system for both structure-function studies and protein export research.
    • Its well-characterized properties facilitate detailed investigation using multiple scientific disciplines.