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Related Experiment Videos

Isolated T wave alternans.

F Navarro-Lopez, J Cinca, G Sanz

    American Heart Journal
    |March 1, 1978
    PubMed
    Summary

    T wave alternans, a heart rhythm disturbance, may indicate underlying issues like severe QT prolongation and hypocalcemia. This electrocardiographic finding could signal transmembrane action potential alternans, increasing ventricular fibrillation risk.

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    Area of Science:

    • Cardiology
    • Electrophysiology
    • Medical Research

    Background:

    • T wave alternans (TWA) is an electrocardiographic phenomenon that can be associated with cardiac arrhythmias.
    • Understanding the clinical significance and underlying mechanisms of TWA is crucial for patient management.

    Observation:

    • This report details two patients with isolated T wave alternans, including their vectocardiograms and responses to interventions.
    • One patient with severe hypocalcemia showed a response to calcium infusion.

    Findings:

    • T wave alternans often co-occurs with severe QT prolongation and QT alternans.
    • These findings suggest T wave alternans may represent transmembrane action potential alternans.
    • A potential link between T wave alternans and hypocalcemia is explored.

    Implications:

    • T wave alternans may serve as an electrocardiographic marker for serious cardiac electrical instability.
    • Further research into the relationship between TWA, QT interval abnormalities, and electrolyte imbalances like hypocalcemia is warranted.
    • Identifying TWA could aid in risk stratification for ventricular fibrillation.

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