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Acute psoriatric arthropathy precipitated by oxprenolol
Annals of the Rheumatic Diseases
|February 1, 1984
Summary
A woman developed psoriatic rash and arthritis after starting oxprenolol for hypertension. Symptoms resolved upon drug discontinuation, indicating a potential drug-induced condition.
Area of Science:
- Dermatology
- Rheumatology
- Clinical Pharmacology
Background:
- Hypertension management often involves beta-blockers like oxprenolol.
- Psoriatic disease encompasses skin and joint manifestations.
- Drug-induced hypersensitivity reactions can mimic autoimmune conditions.
Observation:
- A 58-year-old woman presented with a widespread psoriatic rash.
- Asymmetrical peripheral polyarthritis developed concurrently with the rash.
- These symptoms emerged one week after initiating oxprenolol treatment.
Findings:
- The psoriatic rash and polyarthritis resolved completely after oxprenolol withdrawal.
- No recurrence of skin or joint symptoms was observed post-discontinuation.
- This suggests a causal link between oxprenolol and the observed symptoms.
Implications:
- Oxprenolol may trigger or exacerbate psoriatic disease in susceptible individuals.
- Clinicians should consider drug-induced reactions in patients presenting with new-onset psoriatic manifestations.
- Careful medication review is crucial for managing complex dermatological and rheumatological conditions.