Related Experiment Videos
Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets
To get more information on the mechanism of cell-mediated immunodeficiency associated with Down's syndrome, 18 patients were studied for PHA-induced lymphocyte transformation and interleukin-2 (IL-2) production. A normal amount of IL-2 was produced although half of the patients showed decreased blast transformation. T cell subpopulations were studied in some patients with decreased and with normal blast transformation. All studied patients with decreased blast transformation had inverted helper/suppressor T cell ratio.
To get more information on the mechanism of cell-mediated immunodeficiency associated with Down's syndrome, 18 patients were studied for PHA-induced lymphocyte transformation and interleukin-2 (IL-2) production. A normal amount of IL-2 was produced although half of the patients showed decreased blast transformation. T cell subpopulations were studied in some patients with decreased and with normal blast transformation. All studied patients with decreased blast transformation had inverted helper/suppressor T cell ratio.