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Choroid plexus thrombosis and hemorrhage caused by disseminated intravascular coagulation in Down's syndrome
Human Pathology
|February 1, 1984
Insights
Disseminated intravascular coagulation (DIC) can cause choroid plexus thrombosis and hemorrhage. This rare complication in a patient with Down
Area of Science:
- Neuropathology
- Hematology
- Genetics
Background:
- Disseminated intravascular coagulation (DIC) is a complex hematological disorder.
- Down's syndrome, also known as trisomy 21, is associated with an increased risk of certain infections.
Observation:
- An unusual case of thrombosis and hemorrhage affecting the choroid plexus was observed.
- The patient diagnosed with Down's syndrome presented with these specific neurological findings.
Findings:
- The choroid plexus lesion was directly attributed to disseminated intravascular coagulation (DIC).
- No direct causal link was found between Down's syndrome and the choroid plexus pathology.
- The association was considered coincidental, stemming from increased susceptibility to infections triggering DIC in individuals with Down's syndrome.
Implications:
- Highlights the potential for DIC to manifest as choroid plexus lesions.
- Emphasizes the importance of considering DIC in patients with Down's syndrome presenting with neurological symptoms.
- Clarifies that this specific vascular complication is not an inherent feature of Down's syndrome.
Abstract:
This report concerns an unusual case of thrombosis and hemorrhage in the choroid plexus caused by disseminated intravascular coagulation (DIC). The case is of special interest because it occurred in a patient with Down's syndrome. Nevertheless, there is no causal relation between Down's syndrome and the choroid plexus lesion except that mongols are susceptible to infections that trigger DIC. The association of choroid plexus thrombosis-hemorrhage and Down's syndrome is coincidental and does not indicate a basic vascular defect.