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Adrenocortical function in bronchial asthma.

K G Fehér, E Koó, T Fehér

    Acta Medica Hungarica
    |January 1, 1983
    PubMed
    Summary
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    Female asthma patients show low cortisol and androgen levels, suggesting adrenal insufficiency. This impaired hormone production may impact immune responses, linking asthma to hormonal imbalances.

    Area of Science:

    • Endocrinology
    • Pulmonology
    • Immunology

    Background:

    • Intrinsic bronchial asthma is a chronic respiratory condition.
    • Adrenal hormones, including cortisol and androgens, play roles in immune regulation.
    • Previous research suggests potential links between sex hormones and immune responsiveness.

    Purpose of the Study:

    • To investigate adrenal hormone levels in female patients with intrinsic bronchial asthma.
    • To determine if bronchial asthma is associated with adrenal insufficiency.
    • To explore the relationship between asthma, adrenal androgens, and hormone supply to target organs.

    Main Methods:

    • Assessed blood concentrations of total and free cortisol, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) in female asthma patients.

    Related Experiment Videos

  • Measured urinary excretion of DHEA metabolites.
  • Patients had intrinsic asthma and were not on corticosteroid therapy for at least 3 months.

    • Main Results:

    • Female asthma patients exhibited low blood concentrations of total and free cortisol.
    • Significantly reduced levels of DHEA and DHEA-S were observed in these patients.
    • Urinary excretion of DHEA metabolites was also found to be low.

    Conclusions:

    • Bronchial asthma in these female patients is associated with hypoadrenia (adrenal insufficiency).
    • Impaired production of both cortisol and adrenocortical androgens contributes to insufficient hormone supply.
    • These findings highlight a potential hormonal basis for asthma, possibly involving immune system interactions.