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Related Experiment Videos

Dynamic patch artificial myocardium; effects on the residual myocardial function.

S Kyo, H Emoto, H Yamanaka

    Japanese Circulation Journal
    |March 1, 1984
    PubMed
    Summary
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    Dynamic patch artificial myocardium (D-PATCH) significantly improves cardiac function and metabolism in patients with severe heart conditions. This innovative device aids in salvaging ischemic myocardium while preserving overall heart performance.

    Area of Science:

    • Cardiovascular Engineering
    • Biomedical Devices
    • Regenerative Medicine

    Background:

    • Severe cardiogenic shock and massive myocardial infarction compromise left ventricular (LV) function.
    • Current treatments for end-stage heart failure have limitations.

    Purpose of the Study:

    • To evaluate the efficacy of Dynamic Patch artificial myocardium (D-PATCH) in supporting cardiac function.
    • To assess the impact of D-PATCH on myocardial metabolism.
    • To investigate the combined effects of D-PATCH and aortic counterpulsation (CP).

    Main Methods:

    • Three groups of dogs were studied using whole heart and right heart bypass models.
    • Group 1: Single D-PATCH support on global cardiac function.
    • Group 2: Single D-PATCH support on LV function and metabolism.

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  • Group 3: Concomitant D-PATCH and CP support on regional LV function.

    • Main Results:

    • D-PATCH significantly increased mean aortic pressure (20-36%) and cardiac output (17-50%), while decreasing mean left atrial pressure (16%).
    • D-PATCH reduced tension time index (TTI) by 21-26% and myocardial oxygen consumption by 24-29%.
    • Combined D-PATCH and CP support decreased peak left ventricular pressure (LVP) by 18%, with D-PATCH alone increasing LV segmental shortening by 143%.

    Conclusions:

    • D-PATCH effectively improves global LV function and myocardial metabolism in failing hearts.
    • D-PATCH enhances regional myocardial function of the residual LV wall.
    • D-PATCH is a promising therapy for salvaging ischemic myocardium and maintaining cardiac function.