A protocol for the adoption of analytical methods in the clinical chemistry laboratory

The demand on the clinical chemistry service laboratory to continually adopt more precise and accurate methodologies makes it mandatory for the service laboratory to have a systematic protocol for evaluating and adopting new assay methods. A protocol is presented for adopting clinical chemistry methods in the service laboratory, with emphasis on spectrophotometric determinations. The recommended protocol may be used to evaluate alternate procedures to those currently in use as well as procedures for additional analytes. We present those critical points to be considered in method adoption and instruction for the resolution of each point.