Transhepatic changes in insulin and glucagon following partial hepatectomy in the pig

In this study, glucose levels decreased after partial hepatectomy in the pig. This was associated with a decrease in insulin and an increase in glucagon levels. An added dextrose infusion resulted in hyperglycemia and appropriate responses in insulin and glucagon. Insulin clearance remained unchanged and glucagon extraction by the liver was decreased after partial hepatectomy. Changes in insulin and glucagon after partial hepatectomy appear to be related to the changes in blood glucose rather than the regenerative process.