Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lymphocyte subsets in patients with aplastic anemia.

G J Ruiz-Argüelles, J A Katzmann, P R Greipp

American Journal of Hematology

|April 1, 1984

Summary

Aplastic anemia patients show abnormal T-cell numbers and function, impacting immune response. These findings suggest T-cells may play a role in aplastic anemia progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eco-epidemiological clustering and cluster-wise forecasting of dengue in Mexico, 2020-2025.

Acta tropica·2026

Same author

Generation and characterization of an ovine cell line derived from peripheral blood and its potential use in the study of livestock and zoonotic viral infections.

Virology journal·2025

Same author

Self-reported changes in the expanded disability status scale score in patients with multiple sclerosis after autologous stem cell transplants: real-world data from a single center.

Clinical and experimental immunology·2019

Same author

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10-49 years old: a population-based study from the National Health and Nutrition Examination Survey.

Blood cancer journal·2017

Same author

The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants.

Bone marrow transplantation·2016

Same author

Congenital Acute Megakaryoblastic Leukaemia in Down's Syndrome.

Leukemia & lymphoma·2016

Area of Science:

Immunology
Hematology

Background:

Aplastic anemia is a rare bone marrow failure disorder.
Immune dysregulation is implicated in some cases of aplastic anemia.

Purpose of the Study:

To investigate lymphocyte subsets and T-cell function in patients with aplastic anemia.
To explore the correlation between T-cell abnormalities and disease characteristics or treatment response.

Main Methods:

Enumeration of lymphocyte subsets in 31 aplastic anemia patients.
Assessment of T-cell proliferation in response to pokeweed mitogen (PWM).
Evaluation of suppressor cell activity and correlation with T-cell phenotype.

Main Results:

26% of patients exhibited a reversed helper/suppressor T-cell ratio.

Related Experiment Videos

Reduced T-cell proliferation (hyporesponsiveness) was observed in 7 of 18 patients, particularly those with a reversed ratio.

Suppressor activity was noted in 8 of 18 patients, independent of T-cell phenotype.

Patients with lower T-cell counts showed a higher response rate to treatment (73%) compared to those with normal T-cell counts (26%).

Conclusions:

Abnormalities in T-cell subsets and function are present in a subset of aplastic anemia patients.
These immune alterations may contribute to the pathogenesis of aplastic anemia.
T-cell numbers may predict treatment response in aplastic anemia.