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Prednisone and T-cell subpopulations.

M R Schuyler, A Gerblich, G Urda

    Archives of Internal Medicine
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Glucocorticosteroids like prednisone reduce lymphocytes and eosinophils but do not alter T-cell subsets in peripheral blood. This study examined prednisone

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    The regulation of pulmonary immunity.

    Advances in immunology·1995

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Glucocorticosteroids possess anti-inflammatory and immunoregulatory properties.
    • T-cell subset alterations are implicated in the mechanisms of glucocorticosteroid action.

    Purpose of the Study:

    • To investigate the acute effects of oral prednisone on peripheral blood T-lymphocyte subsets and total eosinophil count (TEC).

    Main Methods:

    • Peripheral blood T-lymphocytes were analyzed for T3, T4, T8, M1, and Ia surface antigens before and after administration of lactose or prednisone.
    • Total eosinophil count was also measured.

    Main Results:

    • Oral lactose did not alter measured values.
    • Prednisone significantly decreased total lymphocyte count (72%) and TEC (97%).

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  • Prednisone did not change the proportion of T cells expressing T3, T4, T8, M1, or Ia antigens.

    • Conclusions:

    • Acute administration of 60 mg prednisone does not selectively deplete specific T-lymphocyte subclasses from peripheral blood.
    • The immunomodulatory effects of prednisone may not be mediated by acute changes in T-cell subset distribution.