Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous amyloidosis in LLC mice.

C K Chai

    The American Journal of Pathology
    |February 1, 1978
    PubMed
    Summary

    Low leukocyte count (LLC) mice develop renal amyloidosis, characterized by amyloid deposits in glomeruli and tubules, leading to kidney failure. This study explores LLC mouse amyloidosis as a model for understanding amyloid diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vibrant soundbridge: a new implantable alternative to conventional hearing AIDS in children.

    The Medical journal of Malaysia·2013
    Same author

    Primary lacrimal sac lymphoma with recurrence: a case report.

    The Medical journal of Malaysia·2013
    Same author

    Simultaneous determination of dextrorphan and guaifenesin in human plasma by liquid chromatography with fluorescence detection.

    Journal of pharmaceutical and biomedical analysis·1995
    Same author

    The inheritance of spontaneous amyloidosis development in mice: a model for hereditary threshold metabolic disorders.

    American journal of medical genetics·1985
    Same author

    Amyloidosis development in LLC mice.

    Experimental cell biology·1984
    Same author

    Hyperplastic growth in skin grafts of rabbits.

    The Journal of heredity·1982

    Area of Science:

    • Nephrology
    • Pathology
    • Immunology

    Background:

    • Low leukocyte count (LLC) is associated with spontaneous renal amyloidosis in mice.
    • Renal amyloidosis in LLC mice involves deposition in glomeruli and interstitial spaces, leading to kidney damage.

    Purpose of the Study:

    • To characterize renal amyloidosis in LLC mice.
    • To evaluate LLC mice as a model for studying amyloidosis.

    Main Methods:

    • Histopathological examination of kidneys from aged LLC mice.
    • Electron microscopy to analyze amyloid fibril deposition and ultrastructural changes.

    Main Results:

    • LLC mice over one year old consistently develop renal amyloidosis.
    • Amyloid fibrils are found in glomerular mesangium, thickened basement membranes, and interstitial spaces.
    • Kidney pathology includes cysts, necrosis, and chronic renal failure.

    Conclusions:

    • LLC mouse amyloidosis serves as a valuable model for amyloidosis research.
    • Further investigation into the etiology and origin of amyloid fibrils in this model is warranted.

    Related Experiment Videos