Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analysis of learning in retarded monkeys.

A S Chamove

    Journal of Mental Deficiency Research
    |March 1, 1984
    PubMed
    Summary

    Phenylketonuria (PKU) monkeys showed no deficits in attention or memory. However, PKU subjects exhibited increased emotionality, impacting learning and response patterns.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Marathon runners' reaction to potassium iontophoretic experimental pain: pain tolerance, pain threshold, coping and self-efficacy.

    European journal of pain (London, England)·2012
    Same author

    Paradox, reprimand and extinction in adults with mental handicap.

    Journal of mental deficiency research·1991
    Same author

    Eating disorders, perceived control, assertiveness and hostility.

    The British journal of clinical psychology·1990
    Same author

    Relaxation reduces disruption in mentally handicapped adults.

    Journal of mental deficiency research·1989
    Same author

    Surveillance evaluation for the elderly.

    Health visitor·1989
    Same author

    Cage design reduces emotionality in mice.

    Laboratory animals·1989

    Area of Science:

    • Neuroscience
    • Behavioral Psychology
    • Developmental Biology

    Background:

    • Phenylketonuria (PKU) is a genetic disorder affecting brain development.
    • Dietary interventions are crucial for managing PKU.
    • Understanding cognitive and emotional impacts of PKU is vital.

    Purpose of the Study:

    • To investigate the learning abilities of rhesus monkeys with diet-induced PKU.
    • To examine potential deficits in attention, memory, and emotional regulation in PKU models.
    • To correlate behavioral findings with existing literature on human and animal PKU.

    Main Methods:

    • Sixteen rhesus monkeys were fed high-phenylalanine or parachlorophenylalanine diets pre- or postpartum.
    • A control group of sixteen monkeys was maintained.
    • Subjects underwent a series of learning tasks post-dietary intervention.

    Main Results:

    • No evidence supported PKU monkeys performing worse with increased task difficulty.
    • No significant attentional or short-term memory deficits were observed.
    • PKU monkeys showed stronger initial biases, less attention to relevant dimensions, and increased emotionality.

    Conclusions:

    • Diet-induced PKU in monkeys does not impair basic learning tasks or memory.
    • Increased emotionality in PKU subjects may explain performance disruptions and response pattern rigidity.
    • Findings contribute to understanding PKU's complex effects on cognitive and emotional behavior.

    Related Experiment Videos