Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ca2+ and the contractile proteins.

S Ebashi

    Journal of Molecular and Cellular Cardiology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Secondary troponin regulation differs between muscle types. Fast skeletal muscle uses a Ca2+-dependent interaction to prevent over-contraction, a mechanism absent in cardiac muscle, potentially causing damage under high calcium conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE.

    The Journal of cell biology·2009
    Same author

    Is phosphorylation the main physiological action of myosin light chain kinase?

    Canadian journal of physiology and pharmacology·1994
    Same author

    [From the window of the "Calcium and Muscle Contraction" Laboratory].

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme·1994
    Same author

    Subgingival plaque formation on single and polycrystal aluminum ceramics.

    The Journal of Nihon University School of Dentistry·1994
    Same author

    [A turning point of the world].

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme·1993
    Same author

    Complexes of myosin subfragment 1 with pyrophosphate and with adenosine diphosphate as studied by phosphorus-31 nuclear magnetic resonance.

    Journal of biochemistry·1993

    Area of Science:

    • Muscle physiology
    • Molecular biology
    • Biochemistry

    Background:

    • Troponin regulation is crucial for muscle contraction and comprises primary and secondary mechanisms.
    • Secondary regulation varies across muscle types, influencing contractile responses.
    • The Ca2+-dependent interaction between troponin T and troponin C is a key secondary regulatory process.

    Purpose of the Study:

    • To investigate the differential roles of secondary troponin regulation in fast skeletal and cardiac muscle.
    • To elucidate the functional significance of the Ca2+-dependent interaction between troponin T and troponin C.

    Main Methods:

    • Comparative analysis of troponin T-troponin C interactions in different muscle types.
    • Examination of myosin-actin-ATP interactions under varying calcium concentrations.

    Related Experiment Videos

    Main Results:

    • A significant Ca2+-dependent suppression of myosin-actin-ATP interaction was observed in fast skeletal muscle at high Ca2+ concentrations (10(-4)M).
    • This suppressive interaction is markedly weaker in cardiac muscle.
    • Fast skeletal muscle exhibits a self-defense mechanism against excessive contraction due to high physiological Ca2+ levels.

    Conclusions:

    • The differential secondary regulation of troponin T and troponin C contributes to muscle-specific contractile properties.
    • The absence of this suppressive mechanism in cardiac muscle may pose risks under pathological high Ca2+ conditions, potentially harming the contractile system.